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Peer-Reviewed Studies ​

Key Studies on Trans Feminine HRT ​

StudyYearKey Findings
de Blok CJM, et al. — Breast cancer risk in transgender people receiving hormone treatment (BMJ)2019Trans women have ~47× higher breast cancer risk than cis men, but ~3× lower than cis women
Nota NM, et al. — Occurrence of acute cardiovascular events (Circulation)2019Low absolute risk of cardiovascular events in trans women on HRT
Connelly PJ, et al. — Managing VTE risk in transgender adults2021Transdermal estradiol has lower VTE risk than oral
Weill A, et al. — CPA and meningioma risk (BMJ)2021Dose-dependent meningioma risk with CPA

Key Studies on Trans Masculine HRT ​

StudyYearKey Findings
van Velzen DM, et al. — Long-term effects of T therapy2021T therapy is safe with appropriate monitoring
Gava G, et al. — Metabolic effects of T therapy2020Minimal adverse metabolic effects in healthy individuals

Clinical Guidelines ​

GuidelineYearPublisher
WPATH SOC82022WPATH
Endocrine Society Guidelines2017Endocrine Society
UCSF Transgender Care Guidelines2016UCSF

How to Access Studies ​

  • PubMed (pubmed.ncbi.nlm.nih.gov) — Free abstracts; some free full text
  • Sci-Hub — Free access to paywalled papers
  • Google Scholar (scholar.google.com) — Free search

References ​

  1. de Blok CJM, et al. (2019). BMJ. https://www.bmj.com/content/365/bmj.l1652

  2. Nota NM, et al. (2019). Circulation. https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.038584

  3. Weill A, et al. (2021). BMJ. https://www.bmj.com/content/372/bmj.n37