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Short-Term Side Effects ​

Common Side Effects ​

Acne ​

DetailsManagement
Very common, especially face/backGentle cleansing twice daily
Peaks at 3–6 monthsBenzoyl peroxide or salicylic acid
Usually improves after 1–2 yearsFor severe acne, see a dermatologist

Bottom Growth Sensitivity ​

DetailsManagement
Clitoral enlargement begins within weeksNormal; tenderness usually subsides
Can be tender during growthWear loose underwear if uncomfortable

Libido Increase ​

DetailsManagement
Very common in first weeks/monthsNormal expected effect
Can be intenseUsually stabilises over time

Hot Flashes ​

DetailsManagement
Can occur as estrogen dropsUsually temporary (1–3 months)
Body adjusting to new hormone balanceEnsure T levels are not too low

Mood Changes ​

DetailsManagement
Increased irritability possibleMonitor your mood
Some feel more confident/assertiveIf severe, check T levels (may be too high)

Appetite and Weight Changes ​

DetailsManagement
Appetite increases significantlyExpected — body needs fuel for muscle growth
Weight gain (mostly lean mass)Healthy diet; regular exercise

When to Seek Medical Attention ​

Emergency signs

  • Sudden severe headache — could be hypertension
  • Vision changes — could be hypertension-related
  • Chest pain / shortness of breath — could be PE or polycythemia-related
  • Severe depression / suicidal thoughts — seek crisis support immediately

References ​

  1. Hembree WC, et al. (2017). Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons. JCEM.